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Ritonavir or lopinavir/ritonavir greatly maximize plasma concentrations of oxycodone in healthful human volunteers due to inhibition of CYP3A4 and CYP2D6.[58] Rifampicin greatly reduces plasma concentrations of oxycodone as a consequence of robust induction of CYP3A4.Stay clear of having grapefruit or drinking grapefruit juice though utilizing this
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